| Human cytokine genes | ||
|---|---|---|
| Strain（abbreviation） | Strain description | Reference |
| NOG-IL2 | Enhanced differentiation of human NK cells, Enhanced proliferation of human T cells | Katano I et al. J Immunol. 2015 |
| NOG-IL2, IL15 | Long-term maintenance of human NK cells | Katano I et al. Sci Rep. 2017 |
| NOG-EXL (NOG-hGM-CSF/hIL-3） | Enhanced differentiation into human myeloid cells | Ito R et al. J Immunol. 2013 |
| NOG-EXL, IL5 | Human eosinophil asthma model | Ito R et al. JCI Insight. 2018 |
| NOG-IL4 | Inhibition of GVHD | Kametani Y et al. PLoS One. 2017 |
| NOG-IL5 | Enhanced differentiation into human eosinophils | Ito R et al. JCI Insight. 2018 |
| NOG-IL6 | Induction of immunosuppressive macrophages | Hanazawa A et al. Front Immunol. 2018 |
| NOG-IL15 | Long-term maintenance of human NK cells | Katano I et al. Sci Rep. 2018 |
| NOG-IL1b/IL23 | Induction of human Th17 cells | Ito R et al. Biochem Biophys Res Commun. 2019 |
| NOG-G-CSF KI | Induction of differentiation into human neutrophils | Ito R et al. Cell Rep. 2022 |
| NOG-M-CSF | Induction of differentiation into human macrophages | |
| C.B17-scid-IL4 | HIV infection model | Okuma K et al. J Infect Dis. 2008 |
| BRG-IL-4 | HIV infection model | Okuma K et al. J Infect Dis. 2008 |
| NOG-IL34 | Differentiation of human microglia | Mathews S et al. Mol Neurodegener. 2019 |
| NOGF-IL15 | Long-term maintenance of human NK cells, decreasing mouse ADCP | Katano I et al. Front Immunol. 2020 |
| MHC/HLA genes | ||
|---|---|---|
| Strain | Strain description | Reference |
| NOG-HLA-A2 Tg | Enhanced human cellular immune responses | |
| NOG-Iab KO, HLA-DR 0405 Tg | Enhanced human cellular immune responses | Suzuki M et al. Int Immunol. 2012 |
| NOG-ΔMHC | Inhibition of GVHD | Ka et al. Immunol Lett. 2020 |
| Human bone marrow microenvironment | ||
|---|---|---|
| Strain | Strain description | Reference |
| NOG-JAG1 | Osteoporosis model | Negishi N et al. Exp Hematol. 2014 |
| NOG-DLL1 | Osteopetrosis-like model | Ito R et al. Exp Hematol. 2012 |
| NOG-Wv/Wv, Wv/+ | Enhanced engraftment of human hematopoietic system cells | |
| NOG-W41 | High engraftment of human hematopoietic cells | Sakurai M et al. Nature. 2023 |
| NOG-Wsh/Wsh | Absence of mouse mast cells | |
| NOGW-EXL | Systemic expression of human IL-3 and GM-CSF in NOG-W41 mice | Ito R et al. Stem Cell Res Ther. 2024 |
| Human liver | ||
|---|---|---|
| Strain | Strain description | Reference |
| uPA-NOG | Human liver model | Suemizu H et al. Biochem Biophys Res Commun. 2008 |
| TK-NOG | Human liver model | Hasegawa M et al. Biochem Biophys Res Commun. 2011 |
| NOG-TKm30 | Human liver model (improved) | Uehara S et al. Drug Metab Pharmacokinet. 2021 |
| Hairless | ||
|---|---|---|
| Strain | Strain description | Reference |
| NOG-Hairless | Hairless NOG mouse | |
| BRG-nude | Hairless BRG mouse | Suemizu H et al. PloS One. 2013 |
| Other | ||
|---|---|---|
| Strain | Strain description | Reference |
| NOG-RORgt Tg | Recovery of mouse lymphatic apparatus | Takahashi T et al. Front Immunol. 2018 |
| NOG-C3 KO | Complement 3 deficient NOG mice | Yamaguchi T et al. Front. Immunol. 2021 |
| NOG-EGFP Tg | Systemic GFP-expressing NOG mice | Suemizu H et al. Exp Anim. 2008 |
| NOG-PGK-EGFP | GFP-expressing NOG mouse | Higuchi Y et al. Exp Anim. 2014 |
| NOG-Ifng Tg | Mouse Ifng overexpressing NOG mouse | |
| NOD-scid-Ifng KO | Ifng deficient NOD-scid mouse | Ito R et al. J Immunol. 2012 |
| BRG | Rag2, Il2rg deficient mouse in the BALB/c background | Traggiai E et al. Science. 2004 |
| BRGS | BRG mouse with Sirpa<NOD>mutation | |
| B6RG | Rag2, Il2rg deficient mouse in the C57BL/6 background | |
| B6RGS | B6RG mouse with Sirpa<NOD> mutation | |
| NR2G | Rag2, Il2rg deficient mouse in the NOD background | Katano I et al. Exp Anim. 2014 |
| NOG-bc KO | NOG background Cytokine common β chain deficient mouse | |
| NOG-mdx | Severe immunodeficient dystrophin gene mutant mouse | Nalbandian M et al. Stem Cell Rep. 2021 |
| NOG-CD155 | Immunological Tolerance Research | Sato K et al. Proc Natl Acad Sci. 2021 |
| NOGF | Immuno-oncology | Katano I et al. Sci Rep. 2021 |
| NOG Ins1 KI | NOG mice exhibiting persistent severe hyperglycemia associated with β-cell depletion | Nakano K et al. Transplantation. 2024 |
| NOG-bp-Jic | Short-limb mutant on NOG mouse background | Kaneko Y et al. Exp Anim. 2025 |
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